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Duration of fever and PA/I38X-substituted virus emergence in patients treated with baloxavir in the 2018-2019 influenza season.
- Source :
-
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2020 Apr; Vol. 26 (4), pp. 400-402. Date of Electronic Publication: 2019 Dec 20. - Publication Year :
- 2020
-
Abstract
- Duration of fever and virus persistence after baloxavir administration were investigated in 81 outpatients, 16 with A(H1N1)pdm09 and 65 with A(H3N2) in the Japanese 2018-2019 influenza season. Only eight cases of A(H3N2) viruses were detected post-dose. PA/I38T-substituted viruses were detected in four (6.2%) of 65 A(H3N2) patients, at days 3 and 4, constituting 50% (4/8) of A(H3N2) detected post-dose. The median duration of fever was 26.0 h for A(H1N1)pdm09 and 20.3 h for A(H3N2). The median duration of fever for patients with PA/I38T-substituted viruses was 22.0 h, without significant difference to that of the patients in whom the mutated virus was not detected. Emergence of PA/I38T-substituted viruses after treatment with baloxavir was confirmed, but no significant prolongation of fever was observed in the four patients with PA/I38T-substituted virus emergence.<br />Competing Interests: Declaration of Competing Interest The authors report no conflicts of interest. The authors alone are responsible for the content in and writing of the paper.<br /> (Copyright © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Drug Resistance, Viral drug effects
Fever
Humans
Influenza A Virus, H1N1 Subtype drug effects
Influenza A Virus, H1N1 Subtype immunology
Influenza A Virus, H3N2 Subtype drug effects
Influenza A Virus, H3N2 Subtype immunology
Middle Aged
Young Adult
Antiviral Agents therapeutic use
Dibenzothiepins therapeutic use
Influenza, Human drug therapy
Morpholines therapeutic use
Pyridones therapeutic use
Triazines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7780
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 31870588
- Full Text :
- https://doi.org/10.1016/j.jiac.2019.12.002