Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region.

Authors :: Carvalho DC
Wanderley AV
Mello Junior FAR
Santos AMRD
Leitão LPC
Souza TP
Castro ANCL
Magalhães LL
Fernandes MR
Carvalho Junior JAN
Khayat AS
Santos S
Assumpção PP
Dos Santos NPC
Source :: Leukemia research reports [Leuk Res Rep] 2019 Nov 27; Vol. 13, pp. 100188. Date of Electronic Publication: 2019 Nov 27 (Print Publication: 2020).
Publication Year :: 2019
Abstract: Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.<br />Competing Interests: The authors declare that they have no competing interests.<br /> (© 2019 The Authors.)

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