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Aspirin antiplatelet effects are associated with body weight.

Authors :: Mourikis P
Zako S
Dannenberg L
Helten C
Naguib D
Hohlfeld T
Petzold T
Levkau B
Zeus T
Kelm M
Polzin A
Source :: Vascular pharmacology [Vascul Pharmacol] 2020 Feb - Mar; Vol. 125-126, pp. 106635. Date of Electronic Publication: 2019 Dec 18.
Publication Year :: 2020
Abstract: Background: Aspirin is indispensable in secondary prevention of ischemic events. Recently, it was reported that clinical aspirin effects are hampered in patients above 70 kg body weight. It is well known that a plethora of reasons beside obesity is associated with increased platelet reactivity and insufficient aspirin effects (HTPR). However, data regarding an association between pharmacodynamic response to aspirin and body weight are missing.<br />Methods: In this pilot study, we included 59 patients from University Hospital Duesseldorf. Impedance aggregometry was used to assess pharmacodynamic response to aspirin.<br />Results: AA-induced platelet reactivity was significantly higher in patients above 70 kg (<70 kg: 28.27 ± 26.33 vs. >70 kg: 45.93 ± 27.1, p = .035) and correlated well with the bodyweight of patients in this study (r = 0.33, R <superscript>2</superscript>  = 0.09, p = .016). According to this, insufficient pharmacodynamic response (HTPR) to aspirin was significantly more frequent in patients over 70 kg (<70 kg: 25% vs. >70 kg: 43%, p = .035).<br />Conclusion: Insufficient pharmacodynamic response to aspirin is associated with body weight. This finding may play a role in the impaired clinical efficacy of aspirin in patients >70 kg. An optimal aspirin regime in these patients needs to be evaluated in large scale trials.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)