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Diffusion tensor imaging tractography reveals altered fornix in all diagnostic subtypes of multiple sclerosis.
- Source :
-
Brain and behavior [Brain Behav] 2020 Jan; Vol. 10 (1), pp. e01514. Date of Electronic Publication: 2019 Dec 19. - Publication Year :
- 2020
-
Abstract
- Introduction: Diffusion tensor imaging (DTI) has shown abnormalities of the fornix and other limbic white matter tracts in multiple sclerosis (MS), mainly focusing on relapsing-remitting MS.<br />Methods: The goal here was to evaluate the fornix, cingulum, and uncinate fasciculus with DTI tractography at 1.7 mm isotropic resolution in three MS subgroups (11 relapsing-remitting (RRMS), nine secondary progressive (SPMS), eight primary progressive (PPMS)) versus 11 controls, and assess correlations with cognitive and clinical scores.<br />Results: The MS group overall showed extensive diffusion abnormalities of the fornix with less volume, lower fractional anisotropy (FA), and higher mean and radial diffusivities, which were similarly affected in all three MS subgroups. The uncinate fasciculus had lower FA only in the secondary progressive subgroup, and the cingulum had no DTI differences in any MS subgroup. The FA and/or volumes of these tracts correlated negatively with larger total lesion volume. The only DTI-cognitive correlation was lower right cingulum FA and greater depression over the entire MS cohort.<br />Conclusions: Diffusion tractography identified abnormalities in the fornix that appears to be affected early and consistently across all three primary MS phenotypes of RRMS, SPMS, and PPMS regardless of Expanded Disability Status Scale, time since diagnosis, or cognitive scores.<br /> (© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.)
- Subjects :
- Adult
Anisotropy
Cognition physiology
Correlation of Data
Female
Humans
Male
Middle Aged
Organ Size
Depression diagnosis
Depression physiopathology
Diffusion Tensor Imaging methods
Fornix, Brain chemistry
Fornix, Brain diagnostic imaging
Fornix, Brain pathology
Multiple Sclerosis classification
Multiple Sclerosis diagnosis
Multiple Sclerosis physiopathology
Multiple Sclerosis psychology
Subjects
Details
- Language :
- English
- ISSN :
- 2162-3279
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 31858742
- Full Text :
- https://doi.org/10.1002/brb3.1514