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A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.

Authors :
Uhlen M
Karlsson MJ
Zhong W
Tebani A
Pou C
Mikes J
Lakshmikanth T
Forsström B
Edfors F
Odeberg J
Mardinoglu A
Zhang C
von Feilitzen K
Mulder J
Sjöstedt E
Hober A
Oksvold P
Zwahlen M
Ponten F
Lindskog C
Sivertsson Å
Fagerberg L
Brodin P
Source :
Science (New York, N.Y.) [Science] 2019 Dec 20; Vol. 366 (6472).
Publication Year :
2019

Abstract

Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.<br /> (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

Details

Language :
English
ISSN :
1095-9203
Volume :
366
Issue :
6472
Database :
MEDLINE
Journal :
Science (New York, N.Y.)
Publication Type :
Academic Journal
Accession number :
31857451
Full Text :
https://doi.org/10.1126/science.aax9198