Back to Search
Start Over
EBV-directed viral-specific T-lymphocyte therapy for the treatment of EBV-driven lymphoma in two patients with primary immunodeficiency and DNA repair defects.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Mar; Vol. 67 (3), pp. e28126. Date of Electronic Publication: 2019 Dec 18. - Publication Year :
- 2020
-
Abstract
- Children with ataxia telangiectasia (AT), a primary immunodeficiency caused by mutations in ATM, which is critical for repairing DNA defects, are at risk for the development of hematologic malignancy, frequently driven by infection with Epstein-Barr virus (EBV). Conventional chemotherapy is poorly tolerated by patients with AT, with excessive toxicity even when doses are reduced. Here, we report on two patients with AT and EBV-positive neoplasms who were treated with EBV-targeted viral-specific T cells (VST). One patient had a prolonged complete response to VSTs while the other had a partial response. Therapy was well tolerated without infusion toxicity or graft-versus-host disease.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Ataxia Telangiectasia etiology
Ataxia Telangiectasia pathology
Ataxia Telangiectasia Mutated Proteins genetics
Child
DNA Damage
Epstein-Barr Virus Infections virology
Female
Hodgkin Disease etiology
Hodgkin Disease pathology
Humans
Immunotherapy methods
Infant
Male
Mutation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma etiology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma pathology
Prognosis
T-Lymphocytes immunology
Virus Activation
Ataxia Telangiectasia therapy
DNA Repair genetics
Epstein-Barr Virus Infections complications
Herpesvirus 4, Human genetics
Hodgkin Disease therapy
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma therapy
T-Lymphocytes transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 67
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 31850668
- Full Text :
- https://doi.org/10.1002/pbc.28126