Four New Picrotoxane-Type Sesquiterpenes From Dendrobium nobile Lindl.

Authors :: Wang P
Chen X
Wang H
Huang S
Cai C
Yuan J
Zhu G
Xu X
Mei W
Dai H
Source :: Frontiers in chemistry [Front Chem] 2019 Nov 29; Vol. 7, pp. 812. Date of Electronic Publication: 2019 Nov 29 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Four picrotoxane-type sesquiterpenes, dendroterpene A-D ( 1 - 4 ), together with four known compounds ( 5 - 8 ), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis, X-ray diffraction analysis, analysis of the ECD data according to the Klyne's lactone sector rule, and quantum ECD calculation. Compounds 1 and 2 are two new picrotoxane-type sesquiterpenes with a new carbon skeleton containing a formamide group, which may be derived from the previously reported dendrobiumane B skeleton by the C(9)-C(11) carbon bond cleavage. Compounds 3 , 5 , 6 , and 8 exhibited inhibitory activity against α-glycosidase. Compounds 5 and 6 were cytotoxic against SGC-7901, K562, A549, BEL-7402, and Hela cell lines.<br /> (Copyright © 2019 Wang, Chen, Wang, Huang, Cai, Yuan, Zhu, Xu, Mei and Dai.)