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Differential diagnosis of pancreatic serous cystadenoma and mucinous cystadenoma: utility of textural features in combination with morphological characteristics.
- Source :
-
BMC cancer [BMC Cancer] 2019 Dec 16; Vol. 19 (1), pp. 1223. Date of Electronic Publication: 2019 Dec 16. - Publication Year :
- 2019
-
Abstract
- Background: Texture analysis of medical images has been reported to be a reliable method for differential diagnosis of neoplasms. This study was to investigate the performance of textural features and the combined performance of textural features and morphological characteristics in the differential diagnosis of pancreatic serous and mucinous cystadenomas.<br />Methods: We retrospectively reviewed 59 patients with pancreatic serous cystadenoma and 32 patients with pancreatic mucinous cystadenoma at our hospital. A three-dimensional region of interest (ROI) around the margin of the lesion was drawn manually in the CT images of each patient, and textural parameters were retrieved from the ROI. Textural features were extracted using the LifeX software. The least absolute shrinkage and selection operator (LASSO) method was applied to select the textural features. The differential diagnostic capabilities of morphological features, textural features, and their combination were evaluated using receiver operating characteristic (ROC) analysis, and the area under the receiver operating characteristic curve (AUC) was used as the main indicator. The diagnostic accuracy based on the AUC value is defined as follows: 0.9-1.0, excellent; 0.8-0.9, good; 0.7-0.8, moderate; 0.6-0.7, fair; 0.5-0.6, poor.<br />Results: In the differential diagnosis of pancreatic serous and mucinous cystadenomas, the combination of morphological characteristics and textural features (AUC 0.893, 95% CI 0.816-0.970) is better than morphological characteristics (AUC 0.783, 95% CI 0.665-0.900) or textural features (AUC 0.777, 95% CI 0.673-0.880) alone.<br />Conclusions: In conclusion, our preliminary results highlighted the potential of CT texture analysis in discriminating pancreatic serous cystadenoma from mucinous cystadenoma. Furthermore, the combination of morphological characteristics and textural features can significantly improve the diagnostic performance, which may provide a reliable method for selecting patients with surgical intervention indications in consideration of the different treatment principles of the two diseases.
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
China
Cystadenoma, Mucinous diagnostic imaging
Cystadenoma, Mucinous pathology
Cystadenoma, Serous diagnostic imaging
Cystadenoma, Serous pathology
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Pancreatic Neoplasms diagnostic imaging
Pancreatic Neoplasms pathology
Retrospective Studies
Young Adult
Cystadenoma, Mucinous diagnosis
Cystadenoma, Serous diagnosis
Multidetector Computed Tomography
Pancreatic Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 31842793
- Full Text :
- https://doi.org/10.1186/s12885-019-6421-7