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Synbiotic fermented soymilk with Weissella cibaria FB069 and xylooligosaccharides prevents proliferation in human colon cancer cells.
- Source :
-
Journal of applied microbiology [J Appl Microbiol] 2020 May; Vol. 128 (5), pp. 1486-1496. Date of Electronic Publication: 2019 Dec 25. - Publication Year :
- 2020
-
Abstract
- Aim: Studies on the anticancer effects of synbiotic fermented soymilk are rare. The aim of the present study was to evaluate the effect of synbiotic fermented soymilk supplemented with xylooligosaccharides and inoculated with Weissella cibaria FB069 (FSMXW) in the proliferation of colon cancer cell and compare it with the effect of soymilk inoculated with Lactobacillus rhamnosus GG (LGG).<br />Methods and Results: Both FB069 and LGG were able to grow in soy-based products and rapidly reduce their pH as a result of fermentation. The addition of XOS significantly enhanced the acidification rate, viscosity and total cell concentration in fermented soymilk inoculated with W. cibaria FB069. However, the same effect was not observed following inoculation with LGG. Moreover, the synbiotic FSMXW showed higher dextran, folate, GABA and aglycone content. FSMXW inhibited the proliferation of Caco-2 and HCT116 cell lines, by reducing the transcription of MD2, TLR4, MyD88, and NF-κb.<br />Conclusions: The synbiotic soymilk containing XOS and W. cibaria FB069 increase nutrient and functional compounds through fermentation process.<br />Significance and Impact of the Study: Our finding suggests that W. cibaria and XOS can be potentially employed in developing functional foods and health-related products.<br /> (© 2019 The Society for Applied Microbiology.)
- Subjects :
- Bioreactors
Caco-2 Cells
Cell Proliferation drug effects
Colonic Neoplasms pathology
Fermentation
Functional Food microbiology
HCT116 Cells
Humans
Lacticaseibacillus rhamnosus growth & development
Lacticaseibacillus rhamnosus metabolism
Weissella growth & development
Antineoplastic Agents pharmacology
Glucuronates metabolism
Oligosaccharides metabolism
Soy Milk chemistry
Synbiotics
Weissella metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2672
- Volume :
- 128
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of applied microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 31834648
- Full Text :
- https://doi.org/10.1111/jam.14551