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Inline cartridge extraction for rapid brain tumor tissue identification by molecular profiling.

Authors :
Pekov SI
Eliferov VA
Sorokin AA
Shurkhay VA
Zhvansky ES
Vorobyev AS
Potapov AA
Nikolaev EN
Popov IA
Source :
Scientific reports [Sci Rep] 2019 Dec 12; Vol. 9 (1), pp. 18960. Date of Electronic Publication: 2019 Dec 12.
Publication Year :
2019

Abstract

The development of perspective diagnostic techniques in medicine requires efficient high-throughput biological sample analysis methods. Here, we present an inline cartridge extraction that facilitates the screening rate of mass spectrometry shotgun lipidomic analysis of tissue samples. We illustrate the method by its application to tumor tissue identification in neurosurgery. In perspective, this high-performance method provides new possibilities for the investigation of cancer pathogenesis and metabolic disorders.

Details

Language :
English
ISSN :
2045-2322
Volume :
9
Issue :
1
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
31831871
Full Text :
https://doi.org/10.1038/s41598-019-55597-7