Back to Search Start Over

Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a "V-shaped" spatial conformation.

Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a "V-shaped" spatial conformation.

Authors :
Yang J
Zeng F
Li X
Ran C
Xu Y
Li Y
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jan 14; Vol. 56 (4), pp. 583-586. Date of Electronic Publication: 2019 Dec 12.
Publication Year :
2020

Abstract

In this report, we demonstrate a "V-shaped" NIRF probe PTO-29, which can monitor Aβ oligomers with high selectivity. PTO-29 was designed and showed significant response to Aβ oligomers in the fluorescence spectral tests and good properties. In vivo imaging results indicate that 4 month APP/PS1 AD mice have higher signals in the brain than age-matched wild type mice.

Details

Language :
English
ISSN :
1364-548X
Volume :
56
Issue :
4
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
31830165
Full Text :
https://doi.org/10.1039/c9cc08894f