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Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a "V-shaped" spatial conformation.
Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a "V-shaped" spatial conformation.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jan 14; Vol. 56 (4), pp. 583-586. Date of Electronic Publication: 2019 Dec 12. - Publication Year :
- 2020
-
Abstract
- In this report, we demonstrate a "V-shaped" NIRF probe PTO-29, which can monitor Aβ oligomers with high selectivity. PTO-29 was designed and showed significant response to Aβ oligomers in the fluorescence spectral tests and good properties. In vivo imaging results indicate that 4 month APP/PS1 AD mice have higher signals in the brain than age-matched wild type mice.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 31830165
- Full Text :
- https://doi.org/10.1039/c9cc08894f