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Pneumococcal Polysaccharide Vaccine Ameliorates Murine Lupus.
- Source :
-
Frontiers in immunology [Front Immunol] 2019 Nov 20; Vol. 10, pp. 2695. Date of Electronic Publication: 2019 Nov 20 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Current guidelines encourage administering pneumococcal vaccine Prevnar-13 to patients with lupus, but whether such vaccinations affect disease severity is unclear. To address this issue, we treated 3-month-old MRL- lpr mice, that spontaneously develop a lupus-like syndrome, with Prevnar-13 or vehicle control. After 3 months, we quantified circulating anti-Pneumococcal polysaccharide capsule (PPS) antibodies and signs of disease severity, including albuminuria, renal histology and skin severity score. We also compared immunophenotypes and function of T and B cells from treated and untreated animals. Prevnar-13 elicited the formation of anti-pneumococcal IgM and IgG. Prevnar-13 treated animals showed reduced albuminuria, renal histological lesions, and milder dermatitis compared to vehicle-treated controls. Mitigated disease severity was associated with reduced and increased T follicular helper cells (T <subscript>FH</subscript> ) and T follicular regulatory cells (T <subscript>FR</subscript> ), respectively, in Prevnar-treated animals. T cells from Prevnar-13 vaccinated mice showed differential cytokine production after aCD3/aCD28 stimulation, with significantly decreased IL-17 and IL-4, and increased IL-10 production compared to non-vaccinated mice. In conclusion, pneumococcal vaccination elicits anti-pneumococcal antibody response and ameliorates disease severity in MRL- lpr mice, which associates with fewer T <subscript>FH</subscript> and increased T <subscript>FR</subscript> . Together, the data support use of Prevnar vaccination in individuals with SLE.<br /> (Copyright © 2019 Cantarelli, Guglielmo, Hartzell, Salem, Andrighetto, Gazivoda, Fiaccadori, La Manna, Zaza, Leventhal, Tassiulas and Cravedi.)
- Subjects :
- Animals
Antibodies, Bacterial immunology
Disease Models, Animal
Mice
Mice, Inbred MRL lpr
Pneumococcal Vaccines pharmacology
T-Lymphocytes drug effects
T-Lymphocytes immunology
Lupus Erythematosus, Systemic immunology
Lupus Erythematosus, Systemic pathology
Pneumococcal Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 10
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 31824490
- Full Text :
- https://doi.org/10.3389/fimmu.2019.02695