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Medulloblastomics revisited: biological and clinical insights from thousands of patients.
- Source :
-
Nature reviews. Cancer [Nat Rev Cancer] 2020 Jan; Vol. 20 (1), pp. 42-56. Date of Electronic Publication: 2019 Dec 09. - Publication Year :
- 2020
-
Abstract
- Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has recently been the focus of intensive molecular profiling efforts, profoundly advancing our understanding of biologically and clinically heterogeneous disease subgroups. Genomic, epigenomic, transcriptomic and proteomic landscapes have now been mapped for an unprecedented number of bulk samples from patients with medulloblastoma and, more recently, for single medulloblastoma cells. These efforts have provided pivotal new insights into the diverse molecular mechanisms presumed to drive tumour initiation, maintenance and recurrence across individual subgroups and subtypes. Translational opportunities stemming from this knowledge are continuing to evolve, providing a framework for improved diagnostic and therapeutic interventions. In this Review, we summarize recent advances derived from this continued molecular characterization of medulloblastoma and contextualize this progress towards the deployment of more effective, molecularly informed treatments for affected patients.
- Subjects :
- Animals
Biomarkers, Tumor
Combined Modality Therapy
Disease Management
Epigenomics methods
Genetic Association Studies
Genomics methods
Humans
Medulloblastoma metabolism
Medulloblastoma therapy
Molecular Diagnostic Techniques
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Proteomics methods
Recurrence
Treatment Outcome
Tumor Microenvironment
Disease Susceptibility
Medulloblastoma diagnosis
Medulloblastoma etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1474-1768
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature reviews. Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 31819232
- Full Text :
- https://doi.org/10.1038/s41568-019-0223-8