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Cytological and functional characteristics of fascia adipocytes in rats: A unique population of adipocytes.
- Source :
-
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2020 Feb; Vol. 1865 (2), pp. 158585. Date of Electronic Publication: 2019 Dec 06. - Publication Year :
- 2020
-
Abstract
- The dermal adipocytes, superficial fascia and subcutaneous adipose tissue (SAT) exist in the interspaces between the dermis and muscular fascia. They are adjacent to each other and traditionally recognized as one SAT. Recently, the dermal adipocyte was redefined as a unique population independent from the SAT. Also, we identified a novel type of adipogenic progenitors in rat superficial fascia. This study aimed to examine cytological and functional characteristics of fascial adipocytes in rats. Superficial fascia had no adipocytes in neonatal rats but gradually appeared numbers of adipocytes in growing rats. Adipogenic progenitors were found to reside in fascia and had strong ability in spontaneous and induced adipogenic differentiation in vitro. Differentiated fascial adipocytes versus subcutaneous or visceral adipocytes expressed increased adipose triglyceride lipase but decreased beta-adrenoreceptor, perilipin-1 and hormone-sensitive lipase (HSL), thus having high basal lipolysis but low lipolysis response to catecholamines. Phosphorylation of perilipin-1 and HSL and translocation of HSL to lipid droplets were attenuated in response to catecholamines rather than post-adrenoreceptoral lipolytic stimulators. The results suggested that superficial fascia was an origin of adipocytes with distinct developmental, cytological and functional characteristics. We proposed that fascial adipocytes could be considered as a unique population of adipocytes in the body. The fascia origin of adipocytes as an adipogenic model might logically explain fat neogenesis occurred at anatomical locations where originally exist no adipose tissues and thereby no adipose-derived stromal precursors. Also, the special histoanatomical relations and overlaps between the dermis, superficial fascia, SAT, and their adipocytes were discussed.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Adipocytes, White cytology
Animals
Catecholamines metabolism
Cell Differentiation physiology
Lipid Droplets metabolism
Male
Mesenchymal Stem Cells physiology
Models, Biological
Perilipin-1 metabolism
Phosphorylation
Rats
Sterol Esterase metabolism
Adipocytes, White metabolism
Lipogenesis physiology
Lipolysis physiology
Subcutaneous Tissue metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-2618
- Volume :
- 1865
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta. Molecular and cell biology of lipids
- Publication Type :
- Academic Journal
- Accession number :
- 31816411
- Full Text :
- https://doi.org/10.1016/j.bbalip.2019.158585