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Oral intake of slowly digestible α -glucan, isomaltodextrin, stimulates glucagon-like peptide-1 secretion in the small intestine of rats.
- Source :
-
The British journal of nutrition [Br J Nutr] 2020 Mar 28; Vol. 123 (6), pp. 619-626. Date of Electronic Publication: 2019 Dec 09. - Publication Year :
- 2020
-
Abstract
- To investigate whether oral intake of highly branched α-glucan isomaltodextrin (IMD) could stimulate ileal glucagon-like peptide-1 (GLP-1) secretion, we examined (1) the digestibility of IMD, (2) the digestion and absorption rates of IMD, in rat small intestine and (3) portal GLP-1 concentration in rats given IMD. In Expt 1, ileorectostomised rats were given a 3 % IMD diet for 10 d. Separately, a 16-h in vitro digestion of IMD, using porcine pancreatic α-amylase and brush-border membrane vesicles from rat small intestine, was conducted. In Expt 2, upon 24-h fasting, rats were given any of glucose, IMD and high-amylose maize starch (HAMS) (1 g/kg of body weight). In Expt 3, caecectomised rats were given 0·2 % neomycin sulphate and a 5 % IMD diet for 10 d. The in vivo and in vitro digestibility of IMD was 70-80 %. The fraction of IMD digested in vitro for the first 120 min was 67 % of that in maize starch. The AUC for 0-120 min of plasma glucose concentration was significantly lower in HAMS group and tended to be lower in IMD group than in the glucose group. Finally, we also observed that, when compared with control rats, glucose of IMD significantly stimulated and improved the concentration of portal active GLP-1 in antibiotic-administered, caecectomised rats. We concluded that IMD was slowly digested and the resulting glucose stimulated GLP-1 secretion in rat small intestine. Oral delivery of slowly released IMD glucose to the small intestine probably exerts important, yet unknown, physiological effects on the recipient.
- Subjects :
- Administration, Oral
Animal Feed analysis
Animals
Area Under Curve
Blood Glucose drug effects
Diet veterinary
Digestion
Gene Expression Regulation drug effects
Half-Life
Male
Maltose administration & dosage
Maltose pharmacology
Rats
Rats, Sprague-Dawley
Dextrins administration & dosage
Dextrins pharmacology
Glucagon-Like Peptide 1 metabolism
Intestine, Small drug effects
Intestine, Small metabolism
Maltose analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 123
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 31813401
- Full Text :
- https://doi.org/10.1017/S0007114519003210