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Hashimotos' thyroiditis: Epidemiology, pathogenesis, clinic and therapy.
- Source :
-
Best practice & research. Clinical endocrinology & metabolism [Best Pract Res Clin Endocrinol Metab] 2019 Dec; Vol. 33 (6), pp. 101367. Date of Electronic Publication: 2019 Nov 26. - Publication Year :
- 2019
-
Abstract
- Hashimoto's thyroiditis (HT), the most frequent autoimmune thyroid disorders (AITDs), is the leading cause of hypothyroidism in the iodine-sufficient areas of the world. About 20-30% of patients suffers from HT, whose cause is thought to be a combination of genetic susceptibility and environmental factors that causes the loss of immunological tolerance, with a consequent autoimmune attack to the thyroid tissue and appearance of the disease. The pathologic features of lymphocytic infiltration, especially of T cells, and follicular destruction are the histological hallmark of autoimmune thyroiditis (AIT), that lead to gradual atrophy and fibrosis. An important role in the immune-pathogenesis of AITDs is due to chemokines and cytokines. In about 20% of patients, AITDs are associated with other organ specific/systemic autoimmune disorders. Many studies have demonstrated the relationship between papillary thyroid cancer and AITD. The treatment of hypothyroidism, as result of AIT, consists in daily assumption of synthetic levothyroxine.<br />Competing Interests: Declaration of Competing Interest The authors have nothing to declare.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Genetic Predisposition to Disease
Hormone Replacement Therapy
Humans
Hypothyroidism diagnosis
Hypothyroidism epidemiology
Hypothyroidism etiology
Hypothyroidism therapy
T-Lymphocytes immunology
Thyroiditis, Autoimmune diagnosis
Thyroiditis, Autoimmune epidemiology
Thyroiditis, Autoimmune etiology
Thyroiditis, Autoimmune therapy
Thyroxine therapeutic use
Hashimoto Disease diagnosis
Hashimoto Disease epidemiology
Hashimoto Disease etiology
Hashimoto Disease therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1594
- Volume :
- 33
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Best practice & research. Clinical endocrinology & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 31812326
- Full Text :
- https://doi.org/10.1016/j.beem.2019.101367