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Real-world Treatment Outcomes of the EXTREME Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Multi-center Retrospective Cohort Study in Japan.
- Source :
-
Anticancer research [Anticancer Res] 2019 Dec; Vol. 39 (12), pp. 6819-6827. - Publication Year :
- 2019
-
Abstract
- Background/aim: This Japanese multiple-center retrospective study aimed to examine the real-world treatment outcomes of the EXTREME regimen as a first-line therapy for recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN).<br />Patients and Methods: A total of 100 R/M SCCHN patients treated with the EXTREME regimen as first-line therapy were analyzed. The treatment outcomes were evaluated to compare patient and treatment characteristics with overall survival.<br />Results: Patients treated with carboplatin-based EXTREME regimen showed similar overall survival with less adverse effects compared to that of patients using cisplatin. The post-progression survival was significantly longer in patients treated with second-line treatment following the EXTREME regimen than in those without second-line treatment.<br />Conclusion: The carboplatin-based EXTREME regimen was more feasible with similar treatment outcomes compared to cisplatin-based EXTREME regimen. In addition, subsequent lines of therapy contributed to improvement of survival for R/M SCCHN patients.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Agents therapeutic use
Carboplatin therapeutic use
Cisplatin therapeutic use
Clinical Trials as Topic
Female
Humans
Japan
Male
Middle Aged
Neoplasm Metastasis
Retrospective Studies
Survival Analysis
Treatment Outcome
Antineoplastic Agents administration & dosage
Carboplatin administration & dosage
Cisplatin administration & dosage
Head and Neck Neoplasms drug therapy
Neoplasm Recurrence, Local drug therapy
Squamous Cell Carcinoma of Head and Neck drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 39
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 31810948
- Full Text :
- https://doi.org/10.21873/anticanres.13898