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Quantitative Evaluation of Percutaneous Local Drug Perfusion Against Refractory Infantile Hemangioma via 3-D Power Doppler Angiography.
- Source :
-
Ultrasound in medicine & biology [Ultrasound Med Biol] 2020 Mar; Vol. 46 (3), pp. 610-619. Date of Electronic Publication: 2019 Dec 03. - Publication Year :
- 2020
-
Abstract
- To assess the practicality of 3-D power Doppler angiography (3-D-CPA) for local drug perfusion dosage guidance of refractory infantile hemangioma (IH) treatment, 47 cases (48 lesions) of refractory IH were selected for local bleomycin infusion (once a month). Ultrasound was performed before treatment and 1 and 2 months after the first treatment. The 3-D volume (V) change of infantile hemangiomas and the ratio of bleomycin injection to 3-D V before treatment were calculated, and statistical analysis was performed. One month after percutaneous local drug perfusion, 37 participants (77.08%) exhibited significant improvement; controlled growth was observed on six lesions (12.5%); and treatment of the remaining 5 lesions (10.42%) failed to suppress growth. The calculated tolerable and effective dose of bleomycin for refractory IH was 0.34 ± 0.03 mL/cm <superscript>3</superscript> ; the corresponding 3-D V decreased approximately 70.27 ± 6.27%. Three-dimensional CPA can provide abundant information on internal lesions. In particular, 3-D-CPA can quantitatively assess changes in lesion volume and guide the effective and rational use of interventional drugs.<br />Competing Interests: Conflict of interest disclosure The authors declare no competing interests.<br /> (Copyright © 2019 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Female
Humans
Infant
Infant, Newborn
Male
Perfusion methods
Retrospective Studies
Angiography methods
Antibiotics, Antineoplastic administration & dosage
Bleomycin administration & dosage
Hemangioma diagnostic imaging
Hemangioma drug therapy
Imaging, Three-Dimensional
Skin Neoplasms diagnostic imaging
Skin Neoplasms drug therapy
Ultrasonography, Doppler
Subjects
Details
- Language :
- English
- ISSN :
- 1879-291X
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Ultrasound in medicine & biology
- Publication Type :
- Academic Journal
- Accession number :
- 31810804
- Full Text :
- https://doi.org/10.1016/j.ultrasmedbio.2019.11.002