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Antioxidation and Antiapoptosis Characteristics of Heme Oxygenase-1 Enhance Tumorigenesis of Human Prostate Carcinoma Cells.
- Source :
-
Translational oncology [Transl Oncol] 2020 Jan; Vol. 13 (1), pp. 102-112. Date of Electronic Publication: 2019 Dec 03. - Publication Year :
- 2020
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Abstract
- Heme oxygenase-1 (HO-1) has antiinflammatory and antioxidant properties and is deemed as a tissue protector. However, effects of HO-1 in prostate cancer remain in controversy. We evaluated the role of HO-1 in prostate carcinoma in vitro and in vivo. Overexpression of HO-1 did not affect prostate cell proliferation in the normal condition but enhanced cell proliferation under serum starvation. HO-1 overexpression enhanced cell invasion of PC-3 cells through epithelial-mesenchymal transition (EMT) induction, which was supported by increased Slug, N-cadherin, and vimentin expressions. In the xenograft animal study, HO-1 overexpression enhanced PC-3 cell tumor growth in vivo. HO-1 attenuated reactive oxygen species induced by H <subscript>2</subscript> O <subscript>2</subscript> or pyocyanin treatment in PC-3 and DU145 cells. HO-1 further reduced PC-3 and DU145 cell apoptosis induced by H <subscript>2</subscript> O <subscript>2</subscript> or serum starvation. Our results suggested that HO-1 was able to increase prostate carcinoma cell invasion in vitro and tumor growth in vivo. The EMT induction and antioxidant and antiapoptotic effects of HO-1 in the prostate carcinoma cells may be responsible for these findings.<br /> (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1936-5233
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Translational oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31810001
- Full Text :
- https://doi.org/10.1016/j.tranon.2019.10.008