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Self-Amplified Photodynamic Therapy through the 1 O 2 -Mediated Internalization of Photosensitizers from a Ppa-Bearing Block Copolymer.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Feb 24; Vol. 59 (9), pp. 3711-3717. Date of Electronic Publication: 2020 Jan 30. - Publication Year :
- 2020
-
Abstract
- Nanocarriers are employed to deliver photosensitizers for photodynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages including the premature leakage and non-selective release of photosensitizers still exist. Herein, we report a <superscript>1</superscript> O <subscript>2</subscript> -responsive block copolymer (POEGMA-b-P(MAA-co-VSPpaMA) to enhance PDT via the controllable release of photosensitizers. Once nanoparticles formed by the block copolymer have accumulated in a tumor and have been taken up by cancer cells, pyropheophorbide a (Ppa) could be controllably released by singlet oxygen ( <superscript>1</superscript> O <subscript>2</subscript> ) generated by light irradiation, enhancing the photosensitization. This was demonstrated by confocal laser scanning microscopy and in vivo fluorescence imaging. The <superscript>1</superscript> O <subscript>2</subscript> -responsiveness of POEGMA-b-P(MAA-co-VSPpaMA) block copolymer enabled the realization of self-amplified photodynamic therapy by the regulation of Ppa release using NIR illumination. This may provide a new insight into the design of precise PDT.<br /> (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Cell Line, Tumor
Cell Survival drug effects
Chlorophyll chemistry
Chlorophyll metabolism
Chlorophyll pharmacology
Chlorophyll therapeutic use
Infrared Rays
Melanoma, Experimental diagnostic imaging
Melanoma, Experimental drug therapy
Mice
Microscopy, Confocal
Particle Size
Photochemotherapy
Photosensitizing Agents metabolism
Photosensitizing Agents pharmacology
Photosensitizing Agents therapeutic use
Polyethylene Glycols chemistry
Porphyrins chemistry
Porphyrins pharmacology
Positron-Emission Tomography
Chlorophyll analogs & derivatives
Nanoparticles chemistry
Photosensitizing Agents chemistry
Polymers chemistry
Singlet Oxygen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 59
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 31808983
- Full Text :
- https://doi.org/10.1002/anie.201914434