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Serotonin type-3 receptors differentially modulate anxiety and aggression during withdrawal from adolescent anabolic steroid exposure.
- Source :
-
Hormones and behavior [Horm Behav] 2020 Mar; Vol. 119, pp. 104650. Date of Electronic Publication: 2019 Dec 15. - Publication Year :
- 2020
-
Abstract
- Male Syrian hamsters (Mesocricetus auratus) administered anabolic/androgenic steroids during adolescent development display increased aggression and decreased anxious behavior during the adolescent exposure period. Upon withdrawal from anabolic/androgenic steroids, this neurobehavioral relationship shifts and hamsters exhibit decreased aggression and increased anxious behavior. This study investigated the hypothesis that alterations in anterior hypothalamic signaling through serotonin type-3 receptors modulate the behavioral shift between adolescent anabolic/androgenic steroid-induced aggressive and anxious behaviors during the withdrawal period. To test this, hamsters were administered anabolic/androgenic steroids during adolescence then withdrawn from drug exposure for 21 days and tested for aggressive and anxious behaviors following direct pharmacological manipulation of serotonin type-3 receptor signaling within the latero-anterior hypothalamus. Blockade of latero-anterior hypothalamic serotonin type-3 receptors both increased aggression and decreased anxious behavior in steroid-treated hamsters, effectively reversing the pattern of behavioral responding normally observed during anabolic/androgenic steroid withdrawal. These findings suggest that the state of serotonin neural signaling within the latero-anterior hypothalamus plays an important role in behavioral shifting between aggressive and anxious behaviors following adolescent exposure to anabolic/androgenic steroids.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Androgens pharmacology
Animals
Behavior, Animal drug effects
Cricetinae
Hypothalamus drug effects
Hypothalamus pathology
Male
Mesocricetus
Receptors, Serotonin, 5-HT3 metabolism
Serotonin pharmacology
Sexual Maturation drug effects
Substance Withdrawal Syndrome metabolism
Substance Withdrawal Syndrome pathology
Testosterone Congeners pharmacology
Aggression drug effects
Anabolic Agents pharmacology
Anxiety chemically induced
Anxiety metabolism
Anxiety pathology
Receptors, Serotonin, 5-HT3 physiology
Substance Withdrawal Syndrome psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6867
- Volume :
- 119
- Database :
- MEDLINE
- Journal :
- Hormones and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 31805280
- Full Text :
- https://doi.org/10.1016/j.yhbeh.2019.104650