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Metabolomic profiles associated with subtypes of prediabetes among Mexican Americans in Starr County, Texas, USA.
- Source :
-
Diabetologia [Diabetologia] 2020 Feb; Vol. 63 (2), pp. 287-295. Date of Electronic Publication: 2019 Dec 04. - Publication Year :
- 2020
-
Abstract
- Aims/hypothesis: To understand the complex metabolic changes that occur long before the diagnosis of type 2 diabetes, we investigated differences in metabolomic profiles in plasma between prediabetic and normoglycaemic individuals for subtypes of prediabetes defined by fasting glucose, 2 h glucose and HbA <subscript>1c</subscript> measures.<br />Methods: Untargeted metabolomics data were obtained from 155 plasma samples from 127 Mexican American individuals from Starr County, TX, USA. None had type 2 diabetes at the time of sample collection and 69 had prediabetes by at least one criterion. We tested statistical associations of amino acids and other metabolites with each subtype of prediabetes.<br />Results: We identified distinctive differences in amino acid profiles between prediabetic and normoglycaemic individuals, with further differences in amino acid levels among subtypes of prediabetes. When testing all named metabolites, several fatty acids were also significantly associated with 2 h glucose levels. Multivariate discriminative analyses show that untargeted metabolomic data have considerable potential for identifying metabolic differences among subtypes of prediabetes.<br />Conclusions/interpretation: People with each subtype of prediabetes have a distinctive metabolomic signature, beyond the well-known differences in branched-chain amino acids.<br />Data Availability: Metabolomics data are available through the NCBI database of Genotypes and Phenotypes (dbGaP, accession number phs001166; www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study&#95;id=phs001166.v1.p1).
- Subjects :
- Adult
Aged
Amino Acids, Branched-Chain blood
Amino Acids, Branched-Chain metabolism
Blood Glucose metabolism
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 metabolism
Fasting blood
Glycated Hemoglobin metabolism
Humans
Mexican Americans
Middle Aged
Multivariate Analysis
Prediabetic State blood
Prediabetic State metabolism
Texas
United States
Young Adult
Metabolomics methods
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0428
- Volume :
- 63
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 31802145
- Full Text :
- https://doi.org/10.1007/s00125-019-05031-4