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Esophageal Adenocarcinoma After Antireflux Surgery in a Cohort Study From the 5 Nordic Countries.
- Source :
-
Annals of surgery [Ann Surg] 2021 Dec 01; Vol. 274 (6), pp. e535-e540. - Publication Year :
- 2021
-
Abstract
- Objective: We aimed to clarify the long-term risk development of EAC after antireflux surgery.<br />Summary of Background Data: Gastroesophageal reflux disease (GERD) increases EAC risk, but whether antireflux surgery prevents EAC is uncertain.<br />Methods: Multinational, population-based cohort study including individuals with GERD from all 5 Nordic countries in 1964-2014. First, EAC risk after antireflux surgery in the cohort was compared with the corresponding background population by calculating standardized incidence ratios (SIRs) with 95% confidence intervals (95% CIs). Second, multivariable Cox proportional hazards regression, providing hazard ratios (HRs) with 95% CIs, compared EAC risk in GERD patients with antireflux surgery with those with nonsurgical treatment.<br />Results: Among 942,071 GERD patients, 48,863 underwent surgery and 893,208 did not. Compared to the corresponding background population, EAC risk did not decrease after antireflux surgery [SIR 4.90 (95% CI 3.62-6.47) 1-<5 years and SIR 4.57 (95% CI 3.44-5.95) ≥15 years after surgery]. Similarly, no decrease was found for patients with severe GERD (esophagitis or Barrett esophagus) after surgery [SIR 6.09 (95% CI 4.39-8.23) 1-<5 years and SIR = 5.27 (95% CI 3.73-7.23) ≥15 years]. The HRs of EAC were stable comparing the surgery group with the nonsurgery group with GERD [HR 1.71 (95% CI 1.26-2.33) 1-<5 years and HR 1.69 (95% CI 1.24-2.30) ≥15 years after treatment], or for severe GERD [HR 1.56 (95% CI 1.11-2.20) 1-<5 years and HR 1.57 (95% CI 1.08-2.26) ≥15 years after treatment].<br />Conclusions: Surgical treatment of GERD does not seem to reduce EAC risk.<br />Competing Interests: The authors report no conflicts of interest.<br /> (Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.)
- Subjects :
- Adenocarcinoma complications
Aged
Esophageal Neoplasms complications
Female
Gastroesophageal Reflux complications
Gastroesophageal Reflux drug therapy
Humans
Incidence
Male
Middle Aged
Proportional Hazards Models
Proton Pump Inhibitors therapeutic use
Risk Factors
Scandinavian and Nordic Countries epidemiology
Adenocarcinoma epidemiology
Esophageal Neoplasms epidemiology
Gastroesophageal Reflux surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1528-1140
- Volume :
- 274
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 31800492
- Full Text :
- https://doi.org/10.1097/SLA.0000000000003709