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Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults.
- Source :
-
NeuroImage. Clinical [Neuroimage Clin] 2019; Vol. 24, pp. 102097. Date of Electronic Publication: 2019 Nov 18. - Publication Year :
- 2019
-
Abstract
- The ability to accurately judge memory efficiency (meta-memory monitoring) for newly learned (episodic) information, is decreased in older adults and even worse in Alzheimer's disease (AD), whereas no differences have been found for semantic meta-memory. The pathological substrates of this phenomenon are poorly understood. Here, we examine the association between meta-memory monitoring for episodic and semantic information to the two major proteinopathies in AD: amyloid (Aβ) and tau pathology in a group of cognitively unimpaired older adults. All participants underwent multi-tracer PET and meta-memory monitoring was assessed using a feeling-of-knowing (FOK) task for non-famous (episodic) and famous (semantic) face-name pairs. Whole brain voxel-wise correlations between meta-memory and PET data were conducted (controlling for memory), as well as confirmatory region-of-interest analyses. Participants had reduced episodic FOK compared to semantic FOK. Decreased episodic FOK was related to tauopathy in the medial temporal lobe regions, including the entorhinal cortex and temporal pole, whereas decreased semantic FOK was related to increased tau in regions associated with the semantic knowledge network. No association was found with Aβ-pathology. Alterations in the ability to accurately judge memory efficiency (in the absence of memory decline) may be a sensitive clinical indicator of AD pathophysiology in the pre-symptomatic phase.<br /> (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Aniline Compounds
Brain metabolism
Carbolines
Contrast Media
Female
Healthy Volunteers
Humans
Male
Middle Aged
Positron-Emission Tomography
Semantics
Tauopathies metabolism
Tauopathies physiopathology
Thiazoles
Amyloid beta-Peptides metabolism
Brain diagnostic imaging
Memory, Episodic
Metacognition physiology
Tauopathies diagnostic imaging
tau Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2213-1582
- Volume :
- 24
- Database :
- MEDLINE
- Journal :
- NeuroImage. Clinical
- Publication Type :
- Academic Journal
- Accession number :
- 31795044
- Full Text :
- https://doi.org/10.1016/j.nicl.2019.102097