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Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms.
- Source :
-
Chemico-biological interactions [Chem Biol Interact] 2020 Jan 05; Vol. 315, pp. 108911. Date of Electronic Publication: 2019 Nov 28. - Publication Year :
- 2020
-
Abstract
- Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Eucommiaceae chemistry
Humans
Plant Extracts pharmacology
Plant Extracts therapeutic use
Cyclopentane Monoterpenes pharmacology
Cyclopentane Monoterpenes therapeutic use
Glucosides pharmacology
Glucosides therapeutic use
Iridoids pharmacology
Iridoids therapeutic use
Pyrans pharmacology
Pyrans therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7786
- Volume :
- 315
- Database :
- MEDLINE
- Journal :
- Chemico-biological interactions
- Publication Type :
- Academic Journal
- Accession number :
- 31786185
- Full Text :
- https://doi.org/10.1016/j.cbi.2019.108911