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Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms.

Authors :
Chan Y
Ng SW
Xin Tan JZ
Gupta G
Tambuwala MM
Bakshi HA
Dureja H
Dua K
Ishaq M
Caruso V
Chellappan DK
Source :
Chemico-biological interactions [Chem Biol Interact] 2020 Jan 05; Vol. 315, pp. 108911. Date of Electronic Publication: 2019 Nov 28.
Publication Year :
2020

Abstract

Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-7786
Volume :
315
Database :
MEDLINE
Journal :
Chemico-biological interactions
Publication Type :
Academic Journal
Accession number :
31786185
Full Text :
https://doi.org/10.1016/j.cbi.2019.108911