The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease.

Authors :: Yang D
Zhao D
Ali Shah SZ
Wu W
Lai M
Zhang X
Li J
Guan Z
Zhao H
Li W
Gao H
Zhou X
Yang L
Source :: Frontiers in neurology [Front Neurol] 2019 Nov 06; Vol. 10, pp. 1155. Date of Electronic Publication: 2019 Nov 06 (Print Publication: 2019).
Publication Year :: 2019
Abstract: It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays a role in several neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease, depression, and multiple sclerosis. Several studies have observed that PD patients generally suffer from gastrointestinal disorders and GM dysbiosis prior to displaying motor symptoms, but the specific link between the GM and PD is not clearly understood. In this review, we aim to summarize what is known regarding the correlation between the GM and PD pathologies, including direct, and indirect evidence.<br /> (Copyright © 2019 Yang, Zhao, Ali Shah, Wu, Lai, Zhang, Li, Guan, Zhao, Li, Gao, Zhou and Yang.)