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A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Dec 10; Vol. 55 (99), pp. 14976-14979. - Publication Year :
- 2019
-
Abstract
- Bicyclo[1.1.1]pentane (BCP) replacement as a bioisostere in drug molecules has an influence on their permeability, aqueous solubility and in vitro metabolic stability. Thus, the chemical installation of the BCP unit into a chemical entity remains a significant challenge from a synthetic point of view. Here, we have presented a new approach for the installation of the BCP unit on the xanthate moiety by means of a radical exchange process.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 55
- Issue :
- 99
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 31776530
- Full Text :
- https://doi.org/10.1039/c9cc07610g