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Spontaneous pancreatic undifferentiated pleomorphic sarcoma in a laboratory rat: A case report.
- Source :
-
Animal models and experimental medicine [Animal Model Exp Med] 2019 Aug 26; Vol. 2 (3), pp. 222-225. Date of Electronic Publication: 2019 Aug 26 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- We present a case of spontaneous undifferentiated/unclassified sarcoma, of a pleomorphic subtype formerly known as malignant fibrous histiocytoma (UPS/MFH), arising from the pancreas of a laboratory rat. The mass was excised after laparotomy from a 6-month-old female laboratory Wistar rat. It presented a giant multilobulated mass of irregular shape, which had arisen from the pancreas and occupied almost the entire peritoneal cavity. Histologically the tumor was characterized by a highly variable morphological pattern, with frequent transitions from storiform to pleomorphic areas. An extensive immunohistochemical examination revealed no specific lines of differentiation. Immunohistochemical positivity was observed only to MIB-1 (high Ki-67 proliferation index), vimentin and CD68 antibodies. The diagnosis was compatible with UPS/MFH. To the best of our knowledge, the present case is the first report of a spontaneous primary UPS/MFH arising from the pancreas of a laboratory rat.<br />Competing Interests: None.<br /> (© 2019 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.)
Details
- Language :
- English
- ISSN :
- 2576-2095
- Volume :
- 2
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Animal models and experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31773099
- Full Text :
- https://doi.org/10.1002/ame2.12078