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Unilateral microscopic gonadoblastoma in a prepubertal Turner mosaic with Y chromosome material identified by restriction fragment analysis.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 1988 Nov; Vol. 90 (5), pp. 622-7. - Publication Year :
- 1988
-
Abstract
- A high incidence of gonadal tumors has been demonstrated in patients with gonadal dysgenesis in the presence of Y chromosome material. A unilateral, microscopic gonadoblastoma was found in the dysgenetic gonad of a ten-year-old, phenotypic female, with Turner stigmata and chromosome mosaicisms of three cell populations 45,X/46,X,+mar,/47,X,+mar,+mar. It is often impossible to determine by cytogenetic analysis if the marker chromosome has derived from the X or Y chromosome. The origin of these marker chromosomes was elucidated by the use of DNA probe (pDP34) for male-specific sequences of the Y chromosome. The presence of Y-specific fragments in the patient's DNA led to surgical exploration and the detection of a gonadoblastoma.
- Subjects :
- Child
Chromosome Mapping
DNA
Dysgerminoma genetics
Dysgerminoma ultrastructure
Female
Humans
Karyotyping
Nucleic Acid Hybridization
Ovarian Neoplasms genetics
Ovarian Neoplasms ultrastructure
Puberty
Turner Syndrome genetics
Turner Syndrome pathology
Dysgerminoma diagnosis
Mosaicism
Ovarian Neoplasms diagnosis
Restriction Mapping
Turner Syndrome diagnosis
Y Chromosome
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9173
- Volume :
- 90
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 3177277
- Full Text :
- https://doi.org/10.1093/ajcp/90.5.622