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Snail modulates JNK-mediated cell death in Drosophila.
- Source :
-
Cell death & disease [Cell Death Dis] 2019 Nov 26; Vol. 10 (12), pp. 893. Date of Electronic Publication: 2019 Nov 26. - Publication Year :
- 2019
-
Abstract
- Cell death plays a pivotal role in animal development and tissue homeostasis. Dysregulation of this process is associated with a wide variety of human diseases, including developmental and immunological disorders, neurodegenerative diseases and tumors. While the fundamental role of JNK pathway in cell death has been extensively studied, its down-stream regulators and the underlying mechanisms remain largely elusive. From a Drosophila genetic screen, we identified Snail (Sna), a Zinc-finger transcription factor, as a novel modulator of ectopic Egr-induced JNK-mediated cell death. In addition, sna is essential for the physiological function of JNK signaling in development. Our genetic epistasis data suggest that Sna acts downstream of JNK to promote cell death. Mechanistically, JNK signaling triggers dFoxO-dependent transcriptional activation of sna. Thus, our findings not only reveal a novel function and the underlying mechanism of Sna in modulating JNK-mediated cell death, but also provide a potential drug target and therapeutic strategies for JNK signaling-related diseases.
- Subjects :
- Animals
Drosophila Proteins metabolism
Drosophila melanogaster embryology
Drosophila melanogaster genetics
Eye cytology
Eye metabolism
Genes, Dominant
Genetic Testing
Larva metabolism
MAP Kinase Signaling System
Phenotype
Snail Family Transcription Factors genetics
Transcription, Genetic
Wings, Animal cytology
Wings, Animal metabolism
Apoptosis
Drosophila melanogaster cytology
Drosophila melanogaster metabolism
JNK Mitogen-Activated Protein Kinases metabolism
Snail Family Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-4889
- Volume :
- 10
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cell death & disease
- Publication Type :
- Academic Journal
- Accession number :
- 31772150
- Full Text :
- https://doi.org/10.1038/s41419-019-2135-7