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Mitochondrial Defects Drive Degenerative Retinal Diseases.
- Source :
-
Trends in molecular medicine [Trends Mol Med] 2020 Jan; Vol. 26 (1), pp. 105-118. Date of Electronic Publication: 2019 Nov 23. - Publication Year :
- 2020
-
Abstract
- Mitochondrial dysfunction is involved in the pathology of two major blinding retinal diseases, diabetic retinopathy (DR) and age-related macular degeneration (AMD). These diseases accumulate mitochondrial defects in distinct retinal subcellular structures, the vascular/neural network in DR and the retinal pigment epithelium (RPE) in AMD. These mitochondrial defects cause a metabolic crisis that drives disease. With no treatments to stop these diseases, coupled with an increasing population suffering from AMD and DR, there is an urgent need to develop new therapeutics targeting the mitochondria to prevent or reverse disease-specific pathology.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1471-499X
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Trends in molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31771932
- Full Text :
- https://doi.org/10.1016/j.molmed.2019.10.008