Co-existence of two novel phosphoethanolamine transferase gene variants in Aeromonas jandaei from retail fish.

Authors :: Liu D
Song H
Ke Y
Xia J
Shen Y
Ou Y
Hao Y
He J
Li X
Zhou Y
Fu J
Wang Y
Lv Z
Wu C
Source :: International journal of antimicrobial agents [Int J Antimicrob Agents] 2020 Jan; Vol. 55 (1), pp. 105856. Date of Electronic Publication: 2019 Nov 23.
Publication Year :: 2020
Abstract: Two novel phosphoethanolamine transferase genes, eptAv7 and eptAv3, were identified in the chromosome of an Aeromonas jandaei isolate from retail fish. The variants showed 79.9% and 80.0% amino acid identity to MCR-7.1 and MCR-3.1, respectively, and increased colistin resistance 128- to 256-fold in Aeromonas salmonicida. The two variants with no mobile genetic element in the flanking regions were also observed in other Aeromonas species. This finding supports the view that Aeromonas is a reservoir for MCR-3 and MCR-7 mobile colistin resistance.<br /> (Copyright © 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.)

Subjects :: Aeromonas drug effects
Aeromonas genetics
Animals
Aquaculture
Drug Resistance, Bacterial
Ethanolamines metabolism
Fishes
Humans
Phylogeny
Whole Genome Sequencing
Aeromonas enzymology
Anti-Bacterial Agents pharmacology
Bacterial Proteins genetics
Colistin pharmacology
Ethanolaminephosphotransferase genetics
Fish Diseases microbiology

Full Text Access

Tools