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The Chicken as a Model Organism to Study Heart Development.
- Source :
-
Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2020 Aug 03; Vol. 12 (8). Date of Electronic Publication: 2020 Aug 03. - Publication Year :
- 2020
-
Abstract
- Heart development is a complex process and begins with the long-range migration of cardiac progenitor cells during gastrulation. This culminates in the formation of a simple contractile tube with multiple layers, which undergoes remodeling into a four-chambered heart. During this morphogenesis, additional cell populations become incorporated. It is important to unravel the underlying genetic and cellular mechanisms to be able to identify the embryonic origin of diseases, including congenital malformations, which impair cardiac function and may affect life expectancy or quality. Owing to the evolutionary conservation of development, observations made in nonamniote and amniote vertebrate species allow us to extrapolate to human. This review will focus on the contributions made to a better understanding of heart development through studying avian embryos-mainly the chicken but also quail embryos. We will illustrate the classic and recent approaches used in the avian system, give an overview of the important discoveries made, and summarize the early stages of cardiac development up to the establishment of the four-chambered heart.<br /> (Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.)
- Subjects :
- Animals
Cell Culture Techniques
Cell Differentiation
Cell Lineage
Cell Movement
Cells, Cultured
Fluorescent Dyes
Heart Defects, Congenital embryology
Heart Ventricles embryology
Humans
Morphogenesis
Neural Crest embryology
Organogenesis
Pericardium embryology
Transgenes
Chick Embryo
Chickens physiology
Heart embryology
Models, Animal
Quail embryology
Quail physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1943-0264
- Volume :
- 12
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cold Spring Harbor perspectives in biology
- Publication Type :
- Academic Journal
- Accession number :
- 31767650
- Full Text :
- https://doi.org/10.1101/cshperspect.a037218