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Biodegradable Inorganic Nanoparticles for Cancer Theranostics: Insights into the Degradation Behavior.
- Source :
-
Bioconjugate chemistry [Bioconjug Chem] 2020 Feb 19; Vol. 31 (2), pp. 315-331. Date of Electronic Publication: 2019 Dec 12. - Publication Year :
- 2020
-
Abstract
- Inorganic nanoparticles as a versatile nanoplatform have been broadly applied in the diagnosis and treatment of cancers due to their inherent superior physicochemical properties (including magnetic, thermal, optical, and catalytic performance) and excellent functions (e.g., imaging, targeted delivery, and controlled release of drugs) through surface functional modification or ingredient dopant. However, in practical biological applications, inorganic nanomaterials are relatively difficult to degrade and excrete, which induces a long residence time in living organisms and thus may cause adverse effects, such as inflammation and tissue cysts. Therefore, the development of biodegradable inorganic nanomaterials is of great significance for their biomedical application. This Review will focus on the recent advances of degradable inorganic nanoparticles for cancer theranostics with highlight on the degradation mechanism, aiming to offer an in-depth understanding of degradation behavior and related biomedical applications. Finally, key challenges and guidelines will be discussed to explore biodegradable inorganic nanomaterials with minimized toxicity issues, facilitating their potential clinical translation in cancer diagnosis and treatment.
- Subjects :
- Animals
Biocompatible Materials analysis
Biocompatible Materials metabolism
Biocompatible Materials therapeutic use
Humans
Inorganic Chemicals analysis
Inorganic Chemicals metabolism
Inorganic Chemicals therapeutic use
Nanoparticles analysis
Nanoparticles metabolism
Nanoparticles ultrastructure
Nanoparticles therapeutic use
Neoplasms diagnosis
Neoplasms therapy
Theranostic Nanomedicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1520-4812
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bioconjugate chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31765561
- Full Text :
- https://doi.org/10.1021/acs.bioconjchem.9b00699