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Biosimilars and Novel Insulins.
- Source :
-
American journal of therapeutics [Am J Ther] 2020 Jan/Feb; Vol. 27 (1), pp. e52-e61. - Publication Year :
- 2020
-
Abstract
- Background: Insulin therapy is the mainstay of treatment for type 1 diabetes and may be necessary in type 2 diabetes. Current insulin analogues present a more physiological profile, are effective, and with less risk of hypoglycemia, but they are expensive. Biosimilar insulins should offer the advantages of insulin analogues at reduced costs. In addition, current rapid-acting insulin analogues are not fast enough to control excessive postprandial glucose excursions in many patients.<br />Areas of Uncertainty: Biosimilar insulins demonstrated that are safe and effective, but interchangeability and automatic substitution remain an issue. Ultrafast-acting insulins should reduce postprandial hyperglycemia and improve flexibility in insulin dosing.<br />Data Sources: This systematic review was conducted following widely recommended methods. We searched for each topic in Medline, Embase, the Cochrane Library, and SCISEARCH for relevant citations for the appropriate period.<br />Therapeutic Advances: LY2963016 and MK-1293 are biosimilar insulins of insulin glargine, and SAR342434 is a biosimilar of insulin lispro. The abbreviated developed program demonstrated comparable efficacy and safety and supports their use for treatment of people with diabetes but no interchangeability. Faster-acting insulin aspart is a new formulation of insulin aspart with accelerated subcutaneous absorption. Faster aspart demonstrated noninferiority in reducing HbA1c as compared to insulin aspart with superiority in controlling postprandial hyperglycemia without increasing hypoglycemia, and flexible insulin dosing.<br />Conclusions: Biosimilar insulins have comparable PK-PD profiles and equivalent efficacy and safety to original insulins at a lower price, making them available for more people with diabetes. Faster aspart is the first ultrafast-acting insulin. New upcoming clinical trials and more clinical experience with faster aspart will show the real potential of this new insulin.
- Subjects :
- Biosimilar Pharmaceuticals pharmacokinetics
Blood Glucose
Diabetes Mellitus, Type 2 drug therapy
Glycated Hemoglobin
Humans
Hyperglycemia drug therapy
Hypoglycemic Agents pharmacokinetics
Insulin Glargine analogs & derivatives
Insulin Glargine pharmacology
Insulin Glargine therapeutic use
Insulin Lispro pharmacology
Insulin Lispro therapeutic use
Randomized Controlled Trials as Topic
Biosimilar Pharmaceuticals pharmacology
Biosimilar Pharmaceuticals therapeutic use
Diabetes Mellitus, Type 1 drug therapy
Hypoglycemic Agents pharmacology
Hypoglycemic Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3686
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 31764128
- Full Text :
- https://doi.org/10.1097/MJT.0000000000001079