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Management of apnea in infants with trisomy 18.
- Source :
-
Developmental medicine and child neurology [Dev Med Child Neurol] 2020 Jul; Vol. 62 (7), pp. 874-878. Date of Electronic Publication: 2019 Nov 25. - Publication Year :
- 2020
-
Abstract
- This case series aimed to characterize the clinical features, management, and outcomes of apnea in infants with trisomy 18. Participants in this study were infants with trisomy 18 who were born alive and admitted to the neonatal intensive care unit in Kyushu University Hospital from 2000 to 2018. Retrospective analysis was performed on clinical data recorded in our department. Twenty-seven infants with trisomy 18 were admitted to our hospital during the study period, of which 25 (nine males, 16 females) were enrolled as eligible participants in this study. Among them, 14 started presenting with apnea from median 3.5 days of age (range 0-47d). In these infants with apnea, eight received respiratory support of positive pressure ventilation (PPV). The 1-year survival rate of infants in the PPV group was higher than that of non-PPV-supported infants (5 out of 8 vs 0 out of 6 infants). Five PPV-supported infants received a diagnosis of epilepsy, which was controlled by antiepileptic drugs. Postnatal respiratory intervention provides better prognosis in infants with trisomy 18. Improved survival leads to accurate diagnosis and treatment of apneic events in association with epilepsy. WHAT THIS PAPER ADDS: Respiratory support is effective against apnea in infants with trisomy 18. Intervention with ventilation provides a higher chance of prolonged survival. Improved survival leads to the accurate diagnosis and treatment of epilepsy-associated apnea.<br /> (© 2019 Mac Keith Press.)
- Subjects :
- Female
Humans
Infant
Infant, Newborn
Male
Retrospective Studies
Apnea diagnosis
Apnea etiology
Apnea mortality
Apnea therapy
Epilepsy diagnosis
Epilepsy mortality
Epilepsy therapy
Intensive Care Units, Neonatal
Outcome Assessment, Health Care
Positive-Pressure Respiration
Trisomy 18 Syndrome complications
Trisomy 18 Syndrome diagnosis
Trisomy 18 Syndrome mortality
Trisomy 18 Syndrome therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1469-8749
- Volume :
- 62
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Developmental medicine and child neurology
- Publication Type :
- Academic Journal
- Accession number :
- 31763690
- Full Text :
- https://doi.org/10.1111/dmcn.14403