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Biomimetic Decoy Inhibits Tumor Growth and Lung Metastasis by Reversing the Drawbacks of Sonodynamic Therapy.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2020 Jan; Vol. 9 (1), pp. e1901335. Date of Electronic Publication: 2019 Nov 25. - Publication Year :
- 2020
-
Abstract
- Sonodynamic therapy (SDT) shows tremendous potential to induce immunogenic cell death (ICD) and activate antitumor immunity. However, it can aggravate hypoxia and release platelet (PLT)-associated danger-associated molecular patterns (DAMPs), which impede therapeutic efficacy and promote tumor metastasis. In order to solve these problems, a biomimetic decoy (designated as Lipo-Ce6/TPZ@M <subscript>H</subscript> ) is constructed to reverse the drawbacks of SDT by loading sonosensitizer chlorin e6 (Ce6) and hypoxia-activated tirapazamine (TPZ) in the red blood cells-PLTs hybrid membrane (M <subscript>H</subscript> )-camouflaged pH-sensitive liposome. After administration, the decoy exhibits enhanced cancer accumulation and retention abilities due to the immune escape and specific targeting behaviors by biomimetic surface coating. Upon local ultrasound, Ce6 produces toxic reactive oxygen species for SDT, and the resulting hypoxia microenvironment activates TPZ, which can realize a high-effective synergistic therapy. Meanwhile, DAMPs-mediated tumor metastasis is significantly inhibited, because the decoy retains platelet binding functions but is incapable of platelet-mediated metastasis. In addition, ICD-mediated strong antitumor immunities further prevent the growth and metastasis of the residual tumors left behind after synergistic treatment. Taken together, this study highlights the potential of using this cascade therapeutic therapy plus biomemitic decoy in one nanosystem to both eliminate melanoma in situ and suppress lung metastasis.<br /> (© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacokinetics
Antineoplastic Agents pharmacology
Apoptosis drug effects
Cell Hypoxia drug effects
Cell Line, Tumor
Chlorophyllides
Humans
Liposomes chemistry
Lung Neoplasms secondary
Melanoma, Experimental pathology
Mice
Mice, Inbred C57BL
Porphyrins chemistry
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species metabolism
Tirapazamine chemistry
Tirapazamine pharmacology
Tirapazamine therapeutic use
Tissue Distribution
Xenograft Model Antitumor Assays
Antineoplastic Agents therapeutic use
Biomimetic Materials chemistry
Lung Neoplasms drug therapy
Ultrasonic Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 31762228
- Full Text :
- https://doi.org/10.1002/adhm.201901335