Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis.

Authors :: Dong H
Lu B
Wang J
Xie J
Liu K
Jia L
Zhuang J
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Dec 05; Vol. 55 (98), pp. 14797-14800.
Publication Year :: 2019
Abstract: We propose a novel fluorescence assay method by designing a polymerization-driven DNA dominoes collapse (PDDC) strategy, enabling highly sensitive detection of p53 gene (as a model analyte) and single nucleotide polymorphism analysis.

Subjects :: Cell Line, Tumor
DNA Probes metabolism
DNA, Neoplasm metabolism
Fluorescence Resonance Energy Transfer
Humans
Inverted Repeat Sequences
Neoplasms diagnosis
Neoplasms genetics
Nucleic Acid Hybridization
Polymerization
Polymorphism, Single Nucleotide
p-Dimethylaminoazobenzene analogs & derivatives
p-Dimethylaminoazobenzene chemistry
DNA Probes chemistry
DNA, Neoplasm analysis
Tumor Suppressor Protein p53 genetics

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