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[Systemic sclerosis and macrovascular involvement: Status of the issue in 2019].
- Source :
-
Journal de medecine vasculaire [J Med Vasc] 2019 Dec; Vol. 44 (6), pp. 400-421. Date of Electronic Publication: 2019 Sep 28. - Publication Year :
- 2019
-
Abstract
- Systemic sclerosis (SSc) is a rare immune disease leading to fibrosis of the skin and internal organs. Microvasculopathy is a hallmark of SSc. However, some patients have severe macrovascular complications as affecting cerebral, cardiac or peripheral vessels. To date, macrovascular involvement in SSc remains a matter of debate. Many studies have shown an increased prevalence of macrovascular involvement in SSc in comparison with controlled subjects with similar cardiovascular risk factors. Various methods were used: ankle brachial pressure index, intima media thickness, imagery, coronary calcium score, pulse wave velocity, or flow mediated dilation. The pathophysiology of macrovascular involvement remains unknown and is probably multifactorial: accelerated atherosclerosis, endothelial dysfunction, or reflected wave of microvessel obliteration. The aim of this study was to perform a comprehensible review of the literature, through the study of different types of involved vessels. Results of the main studies are summarized in tables according to the method of investigation used.<br /> (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adult
Aged
Arteries pathology
Female
Humans
Male
Middle Aged
Prognosis
Risk Factors
Scleroderma, Systemic diagnostic imaging
Scleroderma, Systemic physiopathology
Scleroderma, Systemic therapy
Vascular Diseases diagnostic imaging
Vascular Diseases physiopathology
Vascular Diseases therapy
Arteries physiopathology
Scleroderma, Systemic complications
Vascular Diseases etiology
Vascular Remodeling
Vascular Stiffness
Subjects
Details
- Language :
- French
- ISSN :
- 2542-4513
- Volume :
- 44
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal de medecine vasculaire
- Publication Type :
- Academic Journal
- Accession number :
- 31761307
- Full Text :
- https://doi.org/10.1016/j.jdmv.2019.09.002