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Impact of discontinuation of fish oil after pioglitazone-fish oil combination therapy in diabetic KK mice.
- Source :
-
The Journal of nutritional biochemistry [J Nutr Biochem] 2020 Feb; Vol. 76, pp. 108265. Date of Electronic Publication: 2019 Nov 07. - Publication Year :
- 2020
-
Abstract
- Pioglitazone is one of the thiazolidinediones (TZDs) and an insulin-sensitive drug for type 2 diabetes. In our previous study, a combination of pioglitazone and fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) was shown to inhibit pioglitazone-induced side effects, such as accumulation of subcutaneous fat and body weight gain. However, the effects of the discontinuation of fish oil after combination treatment with TZD and fish oil are not clear. In this study, discontinuation of fish oil for 4 weeks showed several unfavorable effects: (1) return of plasma adiponectin level, (2) reversal of the inhibition of lipogenesis and activation of fatty acid β-oxidation in liver, (3) increase in hypertrophic adipocytes in epidydimal white adipose tissue (WAT) and (4) accumulation of lipids in brown adipose tissue (BAT). However, insulin resistance was ameliorated by pioglitazone with or without fish oil treatment and the discontinuation of fish oil. These findings indicate that discontinuation of n-3 PUFA after combination therapy with TZDs adversely affects lipid metabolism and energy homeostasis in liver, epididymal WAT and BAT.<br />Competing Interests: Conflict of interest The authors declare that they have no competing financial interests.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Adiponectin blood
Adipose Tissue, Brown metabolism
Adipose Tissue, White metabolism
Animals
Body Weight
Cell Differentiation
Homeostasis
Lipid Metabolism
Liver metabolism
Male
Mice
Oxygen metabolism
Adiponectin metabolism
Diabetes Mellitus, Experimental drug therapy
Fish Oils administration & dosage
Insulin Resistance
Pioglitazone administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4847
- Volume :
- 76
- Database :
- MEDLINE
- Journal :
- The Journal of nutritional biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31760227
- Full Text :
- https://doi.org/10.1016/j.jnutbio.2019.108265