Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency.

Objective: Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency.
Case Report: A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Unfractionated heparin was administered from 13 weeks of gestation and rhAT was administered from labor onset. A cesarean section was performed and the patient and her baby were healthy, with no sequelae.
Conclusion: We concluded that rhAT was effective for preventing VTE during delivery, with no potential infection risks.
(Copyright © 2019. Published by Elsevier B.V.)