Chronic myeloid leukemia-derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells.

Authors :: Swatler J
Dudka W
Bugajski L
Brewinska-Olchowik M
Kozlowska E
Piwocka K
Source :: European journal of immunology [Eur J Immunol] 2020 Apr; Vol. 50 (4), pp. 606-609. Date of Electronic Publication: 2019 Dec 05.
Publication Year :: 2020
Abstract: Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis.<br /> (© 2019 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Cells, Cultured
Forkhead Transcription Factors metabolism
Gene Expression Regulation, Leukemic
Humans
Immune Tolerance
Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology
Lymphocyte Activation
Up-Regulation
Extracellular Vesicles metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive metabolism
Neoplastic Stem Cells physiology
T-Lymphocytes, Regulatory immunology
Thymus Gland immunology

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