Surgical outcomes of vitrectomy surgery for proliferative diabetic retinopathy in patients with abnormal renal function.

Purpose: To analyse the influence of renal function on the outcomes of vitrectomy for tractional-related complications in cases of severe proliferative diabetic retinopathy (PDR).
Methods: Retrospective consecutive case series of 109 eyes that underwent vitreoretinal interventions for traction-related complications of severe PDR from 2014 to 2017. Data collected included patient demographics, best-corrected visual acuity (BCVA), surgical complications, and systemic markers including HbA1c and estimated glomerular filtration rate (eGFR). Renal function categories were defined as low (eGFR < 30 mL/min/1.73 m ² ), medium (eGFR 30-60 mL/min/1.73 m ² ), and normal (eGFR > 60 mL/min/1.73m  ² ).
Results: A total of 109 eyes (56% (n = 61) female) were included in the study. Overall, mean baseline BCVA improved from 1.33 logMAR to 0.91 logMAR (p < 0.001) postoperatively. Patients with low eGFR had significantly worse baseline BCVA (p = 0.039) and demonstrated greater improvement in mean BCVA (p = 0.059). Multivariate regression analysis indicated that seven predictors explained 65.5% of the variance (R ²  = 0.655, F(11,97) = 16.7, p < 0.01).
Conclusions: Reduced renal function does not adversely affect visual outcomes of vitrectomy for traction-related complications of PDR.