Rhizophols A and B, antioxidant and axially chiral benzophenones from the endophytic fungus Cytospora rhizophorae.

Two novel polyketones, rhizophols A-B (1-2), were isolated from the endophytic fungus Cytospora rhizophorae A761. They shared unprecedented poly-substituted benzophenone skeletons featuring an epoxy isopentyl unit and a propionyl moiety. Their structures were evidenced by extensive spectroscopic analyses, X-ray diffraction, and quantum energy calculation. Moreover, compound 1 was proved to be a promising lead compound for novel antioxidant drugs.