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[Analysis of related factors affecting evolution of recent small subcortical infarcts with cerebral small vessel disease].
- Source :
-
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2019 Nov 19; Vol. 99 (43), pp. 3420-3423. - Publication Year :
- 2019
-
Abstract
- Objective: To explore related factors affecting evolution of recent small subcortical infarct (RSSI) with small-artery occlusion. Methods: A total of 96 RSSI patients with RSSI were admitted from Shanghai Tongji Hospital between January 2015 and December 2018. The age of patients containing 60 men was 64.5 (58-73) years, and MRI follow-up time was 11.6 (6.3-11.8) months. Clinical information of patients, images data at baseline head MRI and evolution outcomes at follow-up MRI were collected. All patients were divided into cavitation group (lacunes) and no cavitation group (white matter hyperintensities (WMH) and disappearance) to analyze related factors. Results: Fifty-nine cases (61.5%) developed to cavities, 32 cases (33.3%) were focal WMH, and 5 cases (5.2%) disappeared.In the univariate analysis, RSSI maximum diameter on the DWI or T(2)WI sequence of cavitation group was significantly higher than non-cavitation group, but male proportion was lower (11.6 (9.9-16.6) vs 8.6 (6.9-13.0) mm, 11.8 (9.7-16.2) vs 8.8 (6.7-13.1) mm, 54.2% vs 75.7%, all P< 0.05). In Logistic regression analysis,the maximum diameter on DWI sequence was an independent predictor of cavity formation ( P= 0.022, OR= 1.138).When conducting quantitative analysis of infarct diameter and taking infarct maximum diameter ≤10 mm group as reference, the cavitation risk of maximum diameter > 15 mm group was about 7.5 times higher ( P= 0.010, OR= 7.464). The maximum diameter of 10-15 mm lost predictive value for cavity formation ( P= 0.129, OR= 2.444). Conclusions: About 61.5% of RSSI develop to cavitation and 38.5% to WMH or disappear. The RSSI showing larger diameter on DWI has a greater possibility of cavitation.
Details
- Language :
- Chinese
- ISSN :
- 0376-2491
- Volume :
- 99
- Issue :
- 43
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 31752471
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0376-2491.2019.43.014