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NMD Takes the Immune Road to NDD.

Authors :
Kim E
Huh JR
Source :
Neuron [Neuron] 2019 Nov 20; Vol. 104 (4), pp. 625-626.
Publication Year :
2019

Abstract

Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by triggering aberrant immune activation.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1097-4199
Volume :
104
Issue :
4
Database :
MEDLINE
Journal :
Neuron
Publication Type :
Academic Journal
Accession number :
31751540
Full Text :
https://doi.org/10.1016/j.neuron.2019.10.042