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Discriminative stimulus effects of intravenous nicotine in squirrel monkeys.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1988 May; Vol. 30 (1), pp. 243-7. - Publication Year :
- 1988
-
Abstract
- Three squirrel monkeys were trained to emit one response after IV administration of nicotine (0.1 or 0.18 mg/kg depending on the subject) and a different response after IV administration of saline. Subjects emitted nicotine-appropriate responses with substitutions of higher doses, but only emitted saline-appropriate responses after substitutions of lower doses. Discrimination performance was then maintained at 0.1 mg/kg of nicotine in all subjects. Neither morphine nor cocaine substituted for the effects of nicotine in any subjects across a range of doses up to those that suppressed responding. Ethyl-beta-carboline-3-carboxylate, an inverse agonist at the benzodiazepine receptor, substituted or partially substituted for nicotine in both subjects in which it was studied.
Details
- Language :
- English
- ISSN :
- 0091-3057
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 3174749
- Full Text :
- https://doi.org/10.1016/0091-3057(88)90452-2