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Reliable and efficient scale to assess upper motor neuron disease burden in amyotrophic lateral sclerosis.
- Source :
-
Muscle & nerve [Muscle Nerve] 2020 Apr; Vol. 61 (4), pp. 508-511. Date of Electronic Publication: 2019 Dec 20. - Publication Year :
- 2020
-
Abstract
- Background: Validation of biomarkers of upper motor neuron (UMN) impairment in amyotrophic lateral sclerosis (ALS) requires a reliable clinical assessment of UMN findings. The Penn Upper Motor Neuron Score© (PUMNS) is a standardized measure of UMN signs in ALS. Our aims were to evaluate its intra- and inter-rater reliability, and to examine inter-item reliability as a proxy for item relatedness and scale efficiency.<br />Methods: Study procedures were performed during routine clinic visits. We calculated intra and inter-rater reliability using Pearson's correlation coefficient and inter-item reliability using Cronbach's alpha.<br />Results: PUMNS had high intra and inter-rater reliability. Total and sub-score correlation coefficients were all ≥0.96. The inter-item reliability indicated appropriate item relatedness with reasonable efficiency and sub-score correlation coefficients between 0.68 and 0.85.<br />Conclusions: PUMNS is a reliable measure of UMN signs in ALS and would be a useful tool in validating imaging and laboratory biomarkers of UMN injury in ALS.<br /> (© 2019 Wiley Periodicals, Inc.)
Details
- Language :
- English
- ISSN :
- 1097-4598
- Volume :
- 61
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Muscle & nerve
- Publication Type :
- Academic Journal
- Accession number :
- 31743477
- Full Text :
- https://doi.org/10.1002/mus.26764