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Bisphenol compounds regulate decidualized stromal cells in modulating trophoblastic spheroid outgrowth and invasion in vitro†.
- Source :
-
Biology of reproduction [Biol Reprod] 2020 Mar 13; Vol. 102 (3), pp. 693-704. - Publication Year :
- 2020
-
Abstract
- Bisphenol A (BPA) is commonly found in epoxy resins used in the manufacture of plastic coatings in food packaging and beverage cans. There is a growing concern about BPA as a weak estrogenic compound that can affect human endocrine function. Chemicals structurally similar to BPA, such as bisphenol F (BPF) and bisphenol S (BPS), have been developed as substitutes in the manufacturing industry. Whether these bisphenol substitutes have adverse effects on human endocrine and reproductive systems remains largely unknown. This study investigated the effects of BPA, BPF, and BPS on regulating the function of decidualized human primary endometrial stromal cells on trophoblast outgrowth and invasion by indirect and direct co-culture models. All three bisphenols did not affect the stromal cell decidualization process. However, BPA- and BPF-treated decidualized stromal cells stimulated trophoblastic spheroid invasion in the indirect coculture model. The BPA-treated decidualized stromal cells had upregulated expressions of several invasion-related molecules including leukemia inhibitory factor (LIF), whereas both BPA- and BPF-treated decidualized stromal cells had downregulated expressions of anti-invasion molecules including plasminogen activator inhibitor type 1 (PAI-1) and tumor necrosis factor (TNFα) . Taken together, BPA and BPF altered the expression of invasive and anti-invasive molecules in decidualized stromal cells modulating its function on trophoblast outgrowth and invasion, which could affect the implantation process and subsequent pregnancy outcome.<br /> (© The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Cell Line, Tumor
Endometrium metabolism
Female
Humans
Leukemia Inhibitory Factor metabolism
Plasminogen Activator Inhibitor 1 metabolism
Stromal Cells metabolism
Trophoblasts metabolism
Benzhydryl Compounds pharmacology
Endocrine Disruptors pharmacology
Endometrium drug effects
Estrogens, Non-Steroidal pharmacology
Phenols pharmacology
Stromal Cells drug effects
Trophoblasts drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1529-7268
- Volume :
- 102
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biology of reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 31742322
- Full Text :
- https://doi.org/10.1093/biolre/ioz212