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Carboxymethylcellulose/layered double hydroxides bio-nanocomposite hydrogel: A controlled amoxicillin nanocarrier for colonic bacterial infections treatment.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2020 Jul 15; Vol. 155, pp. 1401-1409. Date of Electronic Publication: 2019 Nov 13. - Publication Year :
- 2020
-
Abstract
- In this work, a pH-sensitive carboxymethylcellulose based bio-nanocomposite hydrogel beads with different content of layered double hydroxides (LDHs) as a nanoparticle was prepared (CMC/LDH(Cu/Al)). EDX spectroscopy was used to confirm the successful composition of LDH(Cu/Al) with CMC and its presence in the hydrogel matrix. The prepared CMC/LDH(Cu/Al) bio-nanocomposite hydrogel bead characterized by XRD, FT-IR, and SEM analysis. The swelling results showed the pH-sensitive properties for all of the prepared CMC/LDH(Cu/Al). Amoxicillin (AMX) as a model of the antibiotic drug was selected to study the ability of the prepared systems as an oral drug delivery vehicle. The obtained results showed that the CMC/LDH(Cu/Al 7.5) bio-nanocomposite hydrogel bead has a good performance compared to the other prepared bio-nanocomposites. MTT assay approved the safety of this bio-nanocomposite hydrogel bead against HUVEC cells. Consistent with the obtained results, the prepared hydrogel beads could be potentially proposed as an efficient safe drug carrier for AMX oral delivery.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Amoxicillin therapeutic use
Colon drug effects
Drug Carriers chemistry
Drug Carriers toxicity
Human Umbilical Vein Endothelial Cells
Humans
Microspheres
Nanocomposites chemistry
Safety
Amoxicillin chemistry
Amoxicillin pharmacology
Bacterial Infections drug therapy
Carboxymethylcellulose Sodium chemistry
Colon microbiology
Hydrogels chemistry
Hydroxides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 155
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 31733247
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2019.11.115